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Updated: Apr 10, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Sclerostin: a new biomarker of interest in nephrology]
Solenne Pelletier1, Guillaume Jean2, Denis Fouque3
1Université Lyon 1, Faculté de médecine, Inserm U1033 Physiopathologie, diagnostic et traitements des maladies osseuses et service de néphrologie-dialyse-nutrition, Centre hospitalier Lyon-Sud, France.
Abstract:
Sclerostin is an osteocyte-specific glycoprotein secreted by the osteocyte and involved in the regulation of bone mass. High sclerostin levels are associated with osteoporosis, whereas low sclerostin levels are correlated with higher bone mineral density. It seems interesting to investigate a potential association between sclerostin levels and vascular calcifications since sclerostin is considered as a potent inhibitor of bone formation. In chronic kidney disease, serum sclerostin levels rise as renal function declines. Preliminary studies show a positive association between serum sclerostin and vascular calcification, but the link between sclerostin and survival of patients remains unclear in the absence of large-scale studies.
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