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Aging Research Using Mouse Models.

Cheryl L Ackert-Bicknell1,2, Laura C Anderson1, Susan Sheehan1

  • 1The Jackson Laboratory, Bar Harbor, Maine.

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This study introduces a comprehensive pipeline of phenotypic assays and study designs for mouse models to investigate the genetic basis of aging and health-span. These methods aid researchers in understanding gene-aging relationships.

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age-related diseasehealth-spanmlifespanmousephenotyping

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Area of Science:

  • Gerontology and genetics research.

Background:

  • Human lifespan has increased, but health-span (disease-free period) shows significant variability.
  • Genetic factors are believed to be major contributors to variations in health-span and lifespan.
  • Understanding aging mechanisms and enhancing longevity are key research objectives.

Purpose of the Study:

  • To present a standardized pipeline of phenotypic assays for evaluating mouse models of aging.
  • To outline study design methodologies for assessing lifespan and health-span in aging research.
  • To provide tools for researchers to explore gene-aging correlations.

Main Methods:

  • A pipeline of phenotypic assays including behavior, cognition, body composition, kidney function, hematopoiesis, immune function, and physical parameters.
  • Study design strategies for lifespan and health-span assessment in laboratory mice.
  • Consideration of critical factors in aging research.

Main Results:

  • The described pipeline offers a systematic approach to aging research in mice.
  • The assays facilitate the assessment of age-associated phenotypes.
  • The methodology supports the investigation of genetic influences on aging.

Conclusions:

  • The provided tools and assays are valuable for understanding the genetic underpinnings of aging.
  • This research aids in identifying correlations between age-related phenotypes and specific genes.
  • The pipeline can advance the field of longevity research by clarifying gene-aging interactions.