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Related Concept Videos

Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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Fibril-associated Collagen01:11

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Nephrotic Syndrome I : Introduction01:24

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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Related Experiment Video

Updated: Apr 10, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Collagenofibrotic glomerulopathy-a review.

Rajan Duggal1, Ritambhra Nada1, Charan Singh Rayat1

  • 1Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Clinical Kidney Journal
|June 13, 2015
PubMed
Summary
This summary is machine-generated.

Collagenofibrotic glomerulopathy (CG) is a rare kidney disease causing nephrotic syndrome due to abnormal collagen buildup. Early diagnosis and understanding its pathology are crucial, as no specific treatment currently exists.

Keywords:
Type III collagenbanded collagencollagenofibrotic glomerulopathynephrotic syndrome

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Area of Science:

  • Nephrology
  • Pathology
  • Genetics

Background:

  • Collagenofibrotic glomerulopathy (CG) is a rare nephrotic syndrome.
  • Characterized by abnormal Type III collagen accumulation in glomeruli.
  • Diagnosis confirmed by histology and electron microscopy.

Purpose of the Study:

  • Review clinicopathological features, epidemiology, and pathogenesis of CG.
  • Highlight the importance of considering CG in differential diagnoses.
  • Report three new cases from India.

Main Methods:

  • Literature review of 38 reported CG cases.
  • Analysis of clinicopathological findings.
  • Case illustration from an Indian institute.

Main Results:

  • 22 of 38 reported CG cases are from Asian countries.
  • Three new cases from India are presented.
  • CG shows indolent progression with no specific treatment.

Conclusions:

  • CG is a rare but important differential diagnosis for mesangiocapillary glomerular injury.
  • Understanding its epidemiology and pathogenesis is key.
  • Further research may lead to targeted therapies.