Related Experiment Video
Updated: Apr 10, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Spontaneous coronary artery dissection in polycystic kidney disease
Farah Klingenberg-Salachova1, Sander Limburg2, Frans Boereboom1
1Department of General Medicine, Diakonessenhuis, Utrecht, The Netherlands.
Insights
Autosomal-dominant polycystic kidney disease (ADPKD) may cause unstable arteries, increasing coronary artery dissection (CAD) risk. Early chest pain in ADPKD patients warrants further investigation for missed CAD.
Area of Science:
- Cardiology
- Nephrology
- Genetics
Background:
- Autosomal-dominant polycystic kidney disease (ADPKD) is a genetic disorder affecting the kidneys.
- The association between ADPKD and coronary artery dissection (CAD) is not well-established.
- Vascular abnormalities in ADPKD may predispose individuals to arterial events.
Abstract:
Little is known about the association between autosomal-dominant polycystic kidney disease (ADPKD) and coronary artery dissection (CAD). We suggest that the genetic disorder in ADPKD is the main cause of instable artery vasculature. Our case also shows that CAD can be missed in the acute phase. Therefore, we recommend additional investigation in patients with ADPKD presenting with acute chest pain. We report a case of a patient who developed a myocardial infarction due to a spontaneous dissection of the left anterior descending coronary artery. ADPKD was diagnosed during the additional investigation. The patient received medical management.
More Related Videos
07:35Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
12:47Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
Published on: February 3, 2012
Related Concept Videos
Chronic Kidney Disease I: Introduction
Coronary Artery Disease I: Introduction
Peripheral Artery Disease I: Introduction
Nephrons
External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Cardiac Catheterization I: Pre-Procedure Overview