Related Experiment Video
Updated: Apr 10, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Re-infection following sustained virological response with a different hepatitis C virus genotype: implications for
Michelle M O'Shaughnessy1, John A O'Regan1, Frank E Murray2
1Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Abstract:
We report the case of a 45-year-old haemodialysis patient who achieved a sustained virological response (SVR) following pegylated interferon therapy for hepatitis C virus (HCV) genotype 2 infection. He was subsequently cohorted with other HCV-infected dialysis patients and became re-infected with HCV genotype 3a. Epidemiological and molecular investigations identified a highly viraemic HCV genotype 3a-infected dialysis patient as the likely source of this infection. This critical incident informed a revision to local and national infection control policy regarding the dialysis management of patients who achieve an SVR following anti-viral treatment.
Related Concept Videos
Hepatitis
Viral Recombination
Retrovirus Life Cycles
Viruses with RNA Genomes

