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Effect of continuous positive airway pressure on proteinuria in obstructive sleep apnea
Takahiro Masuda1, Sumiko Honma2, Nobuhiro Sasaki1
1Department of Nephrology, Japanese Red Cross Koga Hospital, Koga, Ibaraki, Japan ; Divisionsof Nephrology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Abstract:
Obstructive sleep apnea (OSA) is common in patients with renal disease, and an association between OSA and proteinuria has been proposed. However, the effect on proteinuria of OSA treatment with continuous positive airway pressure (CPAP) is unknown. We experienced a case of severe OSA, where proteinuria was clearly improved after CPAP initiation without any changes of medication or body weight. The remarkable reduction of repetitive apnea and hypopnea by CPAP might ameliorate proteinuria by lessening renal hypoxia and sympathetic nerve activation. This case suggests that CPAP is a promising option for OSA with proteinuria.
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