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Updated: Apr 10, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis
Huma Fatima1, Edward D Siew2, Jamie P Dwyer2
1Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.
Abstract:
We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.
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