Related Experiment Video
Updated: Apr 10, 2026
04:20
A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
Published on: July 28, 2020
5.7K
[New therapeutical options for heavy gastrointestinal bleeding]
Georg Braun1, Helmut Messmann1
1III. Medizinische Klinik, Klinikum Augsburg.
Deutsche Medizinische Wochenschrift (1946)
|June 13, 2015
Summary
New oral anticoagulants increase bleeding risks. Specific antidotes like Idarucizumab and Andexanet Alfa, alongside endoscopic tools such as Hemospray™, Endoclot™, and new hemostasis clips, offer solutions for managing severe bleeding events.
Area of Science:
- Pharmacology and Gastroenterology
- Medical Device Innovation
Context:
- Increasing use of novel oral anticoagulants (NOACs) correlates with a rise in serious bleeding complications.
- Managing severe bleeding in patients on anticoagulants presents significant clinical challenges.
- Gastrointestinal bleeding is a common and serious adverse event associated with anticoagulant therapy.
Purpose:
- To review the current landscape of managing severe bleeding events in patients using new oral anticoagulants.
- To highlight the availability and application of specific reversal agents and endoscopic hemostatic devices.
Summary:
- Idarucizumab and Andexanet Alfa are specific antidotes for direct thrombin inhibitors and direct Factor Xa inhibitors, respectively.
- Endoscopic treatment options for severe gastrointestinal bleeding include Hemospray™, Endoclot™, and novel hemostasis clips.
- Newly developed hemostasis clips demonstrate efficacy in achieving hemostasis for recurrent ulcer bleeding, potentially avoiding surgery.
Impact:
- Provides clinicians with an overview of advanced therapeutic options for managing anticoagulant-related bleeding.
- Facilitates informed decision-making regarding the use of specific antidotes and endoscopic interventions.
- Highlights innovations in endoscopic hemostasis that may improve patient outcomes and reduce the need for invasive procedures.
Related Concept Videos
01:28Esophageal Varices-II: Clinical Features and Management
796
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
796
01:26Peptic Ulcer Disease IV: Management
669
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
669
01:29Inflammatory Bowel Disease IV: Pharmacological Management
981
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
981
01:21Inflammatory Bowel Disease V: Surgical Management
873
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
873
01:29Venous Thrombosis III: Interprofessional Care
469
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
469
01:23Gastritis III: Clinical Manifestations and Management
1.7K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.7K