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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

[Imported histoplasmosis].

Katarina Stete¹, Winfried V Kern¹, Siegbert Rieg¹

¹Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

Deutsche Medizinische Wochenschrift (1946)

|June 13, 2015

Summary

This summary is machine-generated.

Histoplasma capsulatum infections are uncommon in Germany, often imported. This study details four diverse cases, highlighting varied clinical presentations in both immunocompromised and immunocompetent individuals.

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Area of Science:

Infectious Diseases
Mycology
Clinical Medicine

Background:

Histoplasma capsulatum infections are infrequent in Germany, typically occurring in travelers returning from endemic regions.
The fungus can cause localized or disseminated disease, affecting both immunocompromised and immunocompetent individuals.

Observation:

Four distinct cases of histoplasmosis diagnosed and treated in Freiburg between 2004 and 2013 were analyzed.
Case presentations included chronic basal meningitis in an immunocompetent host, fatal disseminated disease in an HIV-infected patient, pulmonary and cutaneous disease with lymphadenopathy, and disseminated involvement in an immunosuppressed patient.

Findings:

Histoplasmosis presents with a wide spectrum of clinical manifestations.
Travel history is crucial for diagnosing imported cases of histoplasmosis.
Diagnostic methods encompass histology, culture, molecular detection, and serology.

Implications:

Increased awareness of histoplasmosis is necessary, even in non-endemic areas like Germany.
Prompt diagnosis and appropriate treatment are vital for managing diverse clinical presentations of histoplasmosis.
Understanding the broad range of symptoms aids clinicians in suspecting and diagnosing this rare infection.