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Updated: Apr 10, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Autonomic dysfunction in multiple sclerosis
Juan Manuel Racosta1, Kurt Kimpinski1, Sarah Anne Morrow1
1Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada.
Abstract:
Autonomic dysfunction is a prevalent and significant cause of disability among patients with multiple sclerosis. Autonomic dysfunction in multiple sclerosis is usually explained by lesions within central nervous system regions responsible for autonomic regulation, but novel evidence suggests that other factors may be involved as well. Additionally, the interactions between the autonomic nervous system and the immune system have generated increased interest about the role of autonomic dysfunction in the pathogenesis of multiple sclerosis. In this paper we analyze systematically the most relevant signs and symptoms of autonomic dysfunction in MS, considering separately their potential causes and implications.
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