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[Hepatocardiac disorders : Interactions between two organ systems].

T Horvatits1, A Drolz2, K Rutter2

  • 1Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland. t.horvatits@uke.de.

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Summary
This summary is machine-generated.

This article reviews cardiovascular complications in liver disease, including cirrhotic cardiomyopathy (CCMP) and portopulmonary hypertension (POPH). It also discusses hypoxic hepatitis (HH) and current medical therapies for these conditions.

Keywords:
Cardiac outputCardiomyopathiesHepatopulmonary syndromeLiver cirrhosisProstacyclin

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Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Liver disease frequently involves interactions between the hepatic portal and cardiovascular systems.
  • Cirrhotic cardiomyopathy (CCMP) presents as reduced cardiac function in cirrhosis, potentially masked by a hyperdynamic state.
  • Portopulmonary hypertension (POPH) is linked to portal hypertension and elevated mortality.

Purpose of the Study:

  • To provide an overview of cardiovascular complications in liver disease.
  • To define and discuss cirrhotic cardiomyopathy (CCMP), portopulmonary hypertension (POPH), and hypoxic hepatitis (HH).
  • To mention current therapeutic approaches for these conditions.

Main Methods:

  • Literature review of cardiovascular complications in liver disease.
  • Definition and description of CCMP, POPH, and HH.
  • Summary of existing medical therapies.

Main Results:

  • CCMP can present with reduced cardiac function masked by hyperdynamic circulation.
  • POPH is characterized by pulmonary arterial hypertension and portal hypertension, associated with high mortality.
  • Hypoxic hepatitis (HH) results from liver cell necrosis due to circulatory or respiratory failure.

Conclusions:

  • Cardiovascular complications are significant in liver disease patients.
  • Early recognition and management of CCMP, POPH, and HH are crucial.
  • Targeted therapies offer treatment options for these complex conditions.