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Published on: March 14, 2019
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High Rab27A expression indicates favorable prognosis in CRC
Chuanbing Shi1, Xiaojun Yang2, Yijiang Ni3
1Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, 210009, China.
Diagnostic Pathology
|June 14, 2015
Summary
Rab27A protein and mRNA are significantly elevated in colorectal cancer (CRC) tissues. Higher Rab27A expression correlates with advanced CRC, suggesting its potential as a prognostic biomarker for patient survival.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Rab27A, a Rab GTPase, is implicated in human cancer development.
- The role of Rab27A in colorectal cancer (CRC) and its correlation with clinicopathological features remain underexplored.
Purpose of the Study:
- To investigate the expression levels of Rab27A in CRC tissues.
- To determine the association between Rab27A expression and clinicopathological characteristics of CRC.
- To evaluate Rab27A as a prognostic biomarker for CRC patients.
Main Methods:
- Quantitative real-time polymerase chain reaction (qPCR) on 18 fresh-frozen CRC samples.
- Immunohistochemistry (IHC) analysis on 112 CRC cases.
- Cox regression and Kaplan-Meier survival analyses for prognostic factor identification.
Main Results:
- Rab27A mRNA and protein expression were significantly higher in CRC tissues compared to adjacent non-cancerous tissues (qPCR: p=0.029; IHC: p=0.020).
- Rab27A protein expression correlated with lymph node metastasis (p=0.022) and TNM stage (p=0.026).
- Rab27A expression (p=0.012) and tumor differentiation (p=0.004) were significant predictors of overall survival in CRC patients.
Conclusions:
- Rab27A exhibits differential expression in CRC tissues versus non-cancerous tissues.
- Rab27A protein expression is linked to tumor progression and patient survival in CRC.
- Rab27A is a potential prognostic biomarker for colorectal cancer.
