Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

966
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
966
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

623
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
623
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

458
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
458
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

559
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
559
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

544
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
544
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

1.3K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Transcranial Direct Current Stimulation on Multiple Health Outcomes in Neurological Disorders: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials.

Journal of integrative neuroscience·2026
Same author

Natural-product polypharmacology in acute lymphoblastic leukemia: a state-of-the-art review.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Genome-wide identification and characterization of β-defensin genes across sixteen Eulipotyphla species: Insights into gene diversification and evolutionary dynamics.

Developmental and comparative immunology·2026
Same author

Perioperative central retinal artery occlusion after prone posterior cervical spine surgery treated with delayed hyperbaric oxygen therapy: a case report and targeted literature review.

BMC anesthesiology·2026
Same author

A proposed method for locating the tibial attachment for medial patellotibial ligament reconstruction: A cadaveric anatomical and imaging study.

Journal of experimental orthopaedics·2026
Same author

Comparing Outcomes of Heartmate 3 and Heart Transplantation in Older Children With Dilated Cardiomyopathy-Can Transplantation be Delayed or Avoided?

Pediatric transplantation·2026

Related Experiment Video

Updated: Apr 10, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

4.5K

Aortic dilation in pediatric patients.

Yuri A Zarate1,2, Elizabeth Sellars3, Tiffany Lepard4

  • 1Section of Genetics and Metabolism, Department of Pediatrics, The University of Arkansas for Medical Sciences, Little Rock, AR, USA. yazarate@uams.edu.

European Journal of Pediatrics
|June 14, 2015
PubMed
Summary
This summary is machine-generated.

Aortic dilation in children is often linked to congenital heart disease, particularly bicuspid aortic valve. Genetic conditions are frequent, underscoring the need for genetic evaluation in diagnosing aortic root dilation.

Keywords:
Aortic dilationBicuspid aortic valveCongenital heart defectConnective tissue disordersMarfan syndrome

More Related Videos

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

656
Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.9K

Related Experiment Videos

Last Updated: Apr 10, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

4.5K
Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

656
Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.9K

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Genetics
  • Medical Diagnostics

Background:

  • Aortic dilation is frequently associated with congenital heart defects like bicuspid aortic valve and connective tissue disorders.
  • Limited data exists on the differential diagnosis of aortic dilation in pediatric populations.
  • Congenital heart disease is a common comorbidity in children with aortic dilation.

Purpose of the Study:

  • To determine the frequency of various associated diagnoses in children presenting with aortic dilation.
  • To analyze the prevalence of congenital heart disease, genetic syndromes, and other conditions contributing to aortic dilation in pediatric patients.
  • To identify specific diagnoses associated with more severe aortic dilation and need for surgical intervention.

Main Methods:

  • Retrospective analysis of 377 pediatric patients diagnosed with aortic dilation.
  • Classification of patients based on suspected or confirmed diagnoses including congenital heart disease, chromosomal abnormalities, Marfan syndrome, Loeys-Dietz syndrome, and other genetic/non-genetic conditions.
  • Statistical comparison of clinical outcomes, such as severity of dilation and need for surgery, across different diagnostic categories.

Main Results:

  • Congenital heart disease was the most frequent diagnosis (64%), with bicuspid aortic valve being the predominant defect (85% of CHD cases).
  • Genetic conditions, including chromosomal abnormalities (9%) and Marfan syndrome (7%), were also significant contributors to aortic dilation.
  • Patients with Marfan syndrome showed a higher likelihood of severe ascending aorta dilation and aortic root replacement surgery compared to other groups.

Conclusions:

  • The differential diagnosis for pediatric aortic dilation is extensive, necessitating a thorough cardiac anatomical assessment.
  • Given the high prevalence of associated genetic conditions, consultation with a clinical geneticist is strongly recommended.
  • Early identification of underlying causes is crucial for managing aortic dilation and preventing complications.