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Updated: Apr 10, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Gentamicin extended interval regimen and ototoxicity in neonates
Mohamed N El-Barbary1, Rania I H Ismail1, Adel A A Ibrahim2
1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Ramses Street, Cairo, 11566, Egypt.
Extended interval gentamicin dosing in neonatal intensive care units does not increase hearing loss risk. Hearing impairment in neonates may stem from other factors, not gentamicin treatment.
Area of Science:
- Neonatal Medicine
- Pharmacology
- Audiology
Background:
- Gentamicin is a common antibiotic used in neonatal intensive care units (NICUs).
- Concerns exist regarding potential ototoxicity (hearing damage) from gentamicin, especially with extended use.
Purpose of the Study:
- To evaluate the ototoxic effects of an extended interval gentamicin regimen in neonates.
- To compare hearing outcomes between neonates receiving gentamicin and a control group.
Main Methods:
- A cohort study involving 220 neonates in the NICU.
- 110 neonates received gentamicin; 110 served as controls.
- Hearing screening using Transient Evoked Otoacoustic Emissions (TEOAEs), with Auditory Brain Response (ABR) for confirmation.
Main Results:
- No significant difference in hearing impairment rates between gentamicin and control groups (0.9% each).
- Neonates receiving gentamicin for over 5 days showed similar hearing outcomes to those treated for 5 days or less and controls.
- TEOAEs and ABR results were comparable across all groups.
Conclusions:
- Extended interval gentamicin dosing in neonates is not associated with increased hearing loss.
- Ototoxicity from gentamicin may not be a primary cause of hearing impairment in NICU settings.
- Other factors likely contribute to hearing loss in neonates within the NICU environment.
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