Related Experiment Video
Updated: Apr 10, 2026
06:35
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
Published on: April 27, 2016
19.1K
The role of H2S bioavailability in endothelial dysfunction
Rui Wang1, Csaba Szabo2, Fumito Ichinose3
1Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Trends in Pharmacological Sciences
|June 14, 2015
Summary
Hydrogen sulfide (H2S) plays a key role in endothelial dysfunction (EDF), a condition linked to cardiovascular diseases. Restoring H2S levels may offer therapeutic benefits for EDF across various pathologies.
Area of Science:
- Cardiovascular Research
- Endothelial Biology
- Gasotransmitter Signaling
Background:
- Endothelial dysfunction (EDF) involves cellular changes contributing to cardiovascular diseases.
- Hydrogen sulfide (H2S), traditionally an environmental pollutant, is endogenously produced and regulates endothelial function.
- Altered H2S bioavailability is increasingly recognized in EDF pathogenesis.
Purpose of the Study:
- To review the role of hydrogen sulfide (H2S) in the development of endothelial dysfunction (EDF).
- To explore H2S as a potential biomarker and therapeutic target for EDF.
Main Methods:
- Literature review of studies investigating H2S and endothelial dysfunction.
- Analysis of the physiological and pathophysiological roles of H2S in endothelial cells.
- Examination of evidence linking H2S bioavailability to EDF progression and prognosis.
Main Results:
- Endogenous H2S production is crucial for maintaining endothelial integrity and function.
- Disturbances in H2S bioavailability are associated with the progression and severity of EDF.
- H2S influences multiple pathways implicated in EDF across diverse pathologies.
Conclusions:
- Hydrogen sulfide (H2S) is a significant factor in the pathogenesis of endothelial dysfunction (EDF).
- Modulating H2S bioavailability presents a promising therapeutic strategy for EDF.
- Targeting H2S may offer a unified approach to treating EDF-related cardiovascular diseases.
Related Concept Videos
01:20Sulfur Assimilation
511
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
511
01:28Nitric Oxide Signaling Pathway
6.9K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.9K
01:22Bioavailability: Influencing Factors
604
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
604
01:17Bioavailability: Overview
721
Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
721
01:27Bioavailability Enhancement: Drug Permeability Enhancement
308
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
308
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
330
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
330