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Updated: Apr 10, 2026

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
A case of panic to pulmonary embolism
Mansum Ng1, Nikila Pandya2, Brendon Conry3
1Department of Paediatrics, Tunbridge Wells Hospital, Tunbridge Wells, UK.
Pulmonary embolism (PE) is a rare pediatric diagnosis often missed due to subtle symptoms. Even with normal vital signs, PE must be considered, as CT pulmonary angiography is the gold standard for diagnosis.
Area of Science:
- Pediatric Medicine
- Cardiology
- Pulmonology
Background:
- Pulmonary embolism (PE) is an underdiagnosed condition in children.
- PE symptoms are often subtle, non-specific, and mimic other common pediatric illnesses.
- Clinical presentation can range from dyspnea and chest pain to fever and deep vein thrombosis.
Observation:
- The case highlights rare presentations of PE, including abdominal pain and self-resolving shortness of breath.
- Normal vital signs do not exclude the possibility of PE in pediatric patients.
- D-dimer testing in children has limited utility, with up to 40% of pediatric PE cases showing normal D-dimer levels.
Findings:
- CT pulmonary angiography is the definitive diagnostic tool for pediatric PE.
- Early recognition and diagnosis are crucial for effective management and improved outcomes.
- The study underscores the importance of considering PE even with atypical symptoms or normal initial findings.
Implications:
- Clinicians should maintain a high index of suspicion for PE in children presenting with non-specific symptoms.
- Diagnostic strategies for pediatric PE require careful consideration of test limitations, such as D-dimer.
- Further research may elucidate more sensitive diagnostic markers or clinical decision rules for PE in pediatric populations.
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