Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

13.8K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
13.8K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

10.1K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
10.1K
Mitochondria01:37

Mitochondria

21.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.5K
Mitochondria01:37

Mitochondria

4.4K
4.4K
Mitochondrial Membranes01:45

Mitochondrial Membranes

17.9K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.9K
Mitochondrial Membranes01:45

Mitochondrial Membranes

2.4K
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Organ-Specific Changes in the Expression of Inflammatory Response and Antioxidant Defense Genes in the Late Period after Hemorrhagic Shock].

Molekuliarnaia biologiia·2026
Same author

Search for Molecular Markers of Myocardial Injury in a Mouse Model of Obstructive Nephropathy Using Nestin Promoter-Driven GFP Expression.

Bulletin of experimental biology and medicine·2026
Same author

Comparison of Glucose and Glutamine as Energy Substrates for Astrocytes under Conditions of Oxygen Deficiency.

Bulletin of experimental biology and medicine·2026
Same author

Methylene Blue Protects Spatial Working Memory after Traumatic Brain Injury in Mice by Affecting Mitochondrial Quality Control System.

Bulletin of experimental biology and medicine·2025
Same author

The Effects of Threefold 30-Minute Inhalation Sessions of an Argon-Oxygen Mixture on a Photochemically Induced Ischemic Stroke Model in Rats.

Bulletin of experimental biology and medicine·2025
Same author

Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy.

Bulletin of experimental biology and medicine·2024
Same journal

Multidirectional Effects of SARS-CoV-2 Coronavirus Proteins on Amyloid Transformation of Alpha-Synuclein.

Biochemistry. Biokhimiia·2026
Same journal

Dependence of Antioxidant and Transcriptional Responses to Periodic Hypoxia on Sex and Age in Rats.

Biochemistry. Biokhimiia·2026
Same journal

Effect of the PPARγ Agonist Pioglitazone on Rat Behavior and Expression of Epileptogenesis-Related Genes during the Latent Phase of the Lithium-Pilocarpine Model.

Biochemistry. Biokhimiia·2026
Same journal

A Conjugate of Aminoadamantane and Tetrahydro-γ-Carboline Inhibits Accumulation of Mutant α-Synuclein A53T in the Cellular Model of Proteinopathy.

Biochemistry. Biokhimiia·2026
Same journal

Immunoinflammatory Markers in Patients with Affective Disorders: Genetic Polymorphisms, Peripheral Cytokine Levels, and Expression of IL-1β, IL-13, TNF-β, and TGF-α in Peripheral Blood Mononuclear Cells.

Biochemistry. Biokhimiia·2026
Same journal

Method for Individual Assessment of Human Cerebral Cortex Activity by a Combined Use of Magnetic Resonance Spectroscopy of Glutamate and BOLD Signal Method.

Biochemistry. Biokhimiia·2026
See all related articles

Related Experiment Video

Updated: Apr 10, 2026

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells
11:13

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

14.0K

Intercellular Transfer of Mitochondria.

E Y Plotnikov1, V A Babenko, D N Silachev

  • 1Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia. plotnikov@genebee.msu.ru.

Biochemistry. Biokhimiia
|June 15, 2015
PubMed
Summary
This summary is machine-generated.

Intercellular mitochondria transfer aids stem cell differentiation and cell repair. Further research is needed to understand its mechanisms and in vivo relevance for treating mitochondrial diseases.

More Related Videos

Author Spotlight: Bidirectional Mitochondrial Transfer between MSCs and Retinal Pigment Epithelium Cells — Pathways and In Vivo Challenges
06:50

Author Spotlight: Bidirectional Mitochondrial Transfer between MSCs and Retinal Pigment Epithelium Cells — Pathways and In Vivo Challenges

Published on: October 4, 2024

1.8K
Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

40.9K

Related Experiment Videos

Last Updated: Apr 10, 2026

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells
11:13

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

14.0K
Author Spotlight: Bidirectional Mitochondrial Transfer between MSCs and Retinal Pigment Epithelium Cells — Pathways and In Vivo Challenges
06:50

Author Spotlight: Bidirectional Mitochondrial Transfer between MSCs and Retinal Pigment Epithelium Cells — Pathways and In Vivo Challenges

Published on: October 4, 2024

1.8K
Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

40.9K

Area of Science:

  • Cell Biology
  • Mitochondrial Biology
  • Translational Medicine

Background:

  • Intercellular mitochondria transfer is a recently identified phenomenon with significant implications.
  • This process influences stem cell differentiation, cell reprogramming, and restoration of mitochondrial function.
  • Current understanding of the mechanisms and in vivo occurrence of mitochondria transfer remains limited.

Purpose of the Study:

  • To investigate the mechanisms of intercellular mitochondria transfer.
  • To explore the conditions that induce mitochondria transfer between cells.
  • To examine the role of the ubiquitination system in regulating mitochondria transfer into somatic cells.

Main Methods:

  • The study involves investigating the molecular mechanisms of mitochondria transfer.
  • Research focuses on the ubiquitination system's role in regulating this process.
  • In vivo studies are proposed to validate the phenomenon.

Main Results:

  • Mitochondria transfer can initiate stem cell differentiation and reprogram cells.
  • It can restore mitochondrial function in recipient cells.
  • The ubiquitination system's influence on mitochondria transfer requires further elucidation.

Conclusions:

  • Understanding mitochondria transfer mechanisms is crucial for therapeutic strategies.
  • Further research can unlock new avenues for treating mitochondrial pathologies.
  • Mitochondrial transplantation holds promise for regenerative medicine.