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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Related Experiment Video

Updated: Apr 10, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
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Remote ischaemic preconditioning in intermittent claudication.

Hermeland Delagarde1, Nafi Ouadraougo2, Sylvain Grall1

  • 1L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France.

Archives of Cardiovascular Diseases
|June 15, 2015
PubMed
Summary
This summary is machine-generated.

Remote ischaemic preconditioning (RIPC) did not improve walking ability in patients with intermittent claudication. This study found no significant difference in walking distance or limb oxygenation after RIPC compared to a control procedure.

Keywords:
Artériopathie oblitérante des membres inférieursConditionnement ischémique à distanceIschaemia-reperfusionIschémie-reperfusionPeripheral artery diseaseRemote conditioning

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Area of Science:

  • Cardiovascular Research
  • Vascular Surgery
  • Clinical Trials

Background:

  • Remote ischaemic preconditioning (RIPC) is a protective strategy against ischaemia-reperfusion (I/R) injury.
  • Peripheral artery disease (PAD) and intermittent claudication (IC) significantly impact patient mobility and quality of life.

Purpose of the Study:

  • To investigate the efficacy of RIPC in improving walking disability in patients with arterial intermittent claudication.
  • To assess the impact of RIPC on exercise capacity and limb oxygenation in IC patients.

Main Methods:

  • A randomized crossover trial involving 20 patients with intermittent claudication.
  • Patients underwent two treadmill tests, receiving either RIPC or a control procedure before each test.
  • Limb oxygenation was measured using transcutaneous oximetry and near-infrared spectroscopy.

Main Results:

  • No significant difference in walking distances was observed between the RIPC and control procedures (204m vs 215m, P=0.22).
  • Limb oxygenation parameters, including transcutaneous oxygen pressure and near-infrared spectroscopy measurements, showed no significant changes.
  • Exercise intensity was comparable between the RIPC and control conditions.

Conclusions:

  • Remote ischaemic preconditioning (RIPC) does not improve walking distance in patients with peripheral artery disease and intermittent claudication.
  • RIPC did not demonstrate a beneficial effect on limb ischaemia variables during exercise in this patient cohort.