Related Experiment Video

Updated: Jan 14, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

2.9K

An update on the role of miRNA-155 in pathogenic microbial infections

Fu-Rong Zeng1, Li-Jun Tang1, Ye He1

  • 1The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, Hunan, China.

Microbes and Infection
|June 15, 2015
PubMed

Insights

MicroRNAs (miRNAs), including miR-155, regulate gene expression and are vital for development. This review explores miR-155's significant role in the body's response to various infectious diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression post-transcriptionally.
  • MiR-155 is a key miRNA involved in cell differentiation, proliferation, apoptosis, and immune responses.
  • Emerging research highlights miR-155's involvement in physiological and pathological processes, including infectious diseases.

Purpose of the Study:

  • To review the critical role of miR-155 in host responses to infections.
  • To consolidate current understanding of miR-155's function in various pathogen-induced diseases.

Main Methods:

  • Literature review of studies investigating miR-155 in the context of infectious diseases.
  • Analysis of experimental data on miR-155's regulatory functions during infection.

Main Results:

  • MiR-155 modulates key pathways involved in inflammation and immunity during infection.
  • Dysregulation of miR-155 is associated with disease progression in various infectious conditions.
  • Specific examples of miR-155's role in response to viral, bacterial, and parasitic infections are discussed.

Conclusions:

  • MiR-155 is a crucial regulator in the immune response to pathogens.
  • Targeting miR-155 may offer therapeutic strategies for infectious diseases.
  • Further research is warranted to fully elucidate miR-155's complex roles in infection.
Keywords:
Bacterial infectionHost cellsViral infectionmiR-155

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.9K
MicroRNA-based Regulation of Picornavirus Tropism09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.0K

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
928
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.5K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
27.8K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.3K