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CyHV-2 ORF104 activates the p38 MAPK pathway

Mi Du1, Mingliang Chen2, Haifeng Shen2

  • 1School of Marine Sciences, Ningbo University, Ningbo, 315211 Zhejiang, China; State Key Laboratory Breeding Base of Marine Genetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, State Oceanic Administration, Xiamen, 361005 Fujian, China.

Fish & Shellfish Immunology
|June 15, 2015
PubMed
Summary

Cyprinid herpesvirus 2 (CyHV-2) ORF104 protein activates the p38 signaling pathway, crucial for viral infection. Inhibiting p38 reduces fish mortality, identifying ORF104 as a potential vaccine target.

Keywords:
Cyprinid herpesvirus 2Gibel carpORF104p38

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