Ranolazine overdose-induced seizures.
Nour Akil1, Edward Bottei2, Sameer Kamath1
1Stead Family Department of Pediatrics, University of Iowa Children's Hospital, Iowa City, IA.
The American Journal of Emergency Medicine
|June 15, 2015
Summary
Ranolazine overdose can cause new-onset seizures in adolescents, a previously unreported adverse effect. This case highlights the critical need for vigilance in pediatric intensive care following intentional ranolazine ingestion.
Area of Science:
- Cardiology
- Neurology
- Clinical Toxicology
Background:
- Ranolazine, approved by the US Food and Drug Administration (FDA) in 2006, is an anti-anginal medication for symptomatic chronic angina.
- It is typically prescribed for patients whose condition persists despite optimized standard therapies.
Observation:
- A case report details a 15-year-old male admitted to a pediatric intensive care unit following an overdose of ranolazine.
- The patient presented with recurrent, new-onset seizures.
Findings:
- The seizures were strongly suspected to be a direct consequence of the ranolazine overdose.
- This represents the first reported instance of seizures associated with ranolazine use or abuse in medical literature.
Implications:
- This case suggests a potential neurological adverse effect of ranolazine, particularly in overdose scenarios.
- Increased awareness and monitoring for seizures are warranted in pediatric patients with ranolazine overdose.
- Further research may be needed to elucidate the mechanism linking ranolazine to seizure activity.
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