[Prognostication of malignization and acute complications of gastric ulcer disease, using multiparametric neuronet clasterization]

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Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

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Published on: February 16, 2024

I Ya Dzyubanovskiy, P R Selskiy, L E Viytovych

Klinichna Khirurhiia

|June 16, 2015

Abstract:

Results of examination of 20 gastric ulcer disease patients were analyzed for delineation of a high risk group for an acute complications occurrence, and in whom the conduction of organ preserving preventive operative interventions is expedient. For prognostication such following indices were applied: quantity of cells-producents of various immunoglobulins, mitotic and apoptotic indices, relative volume of damaged epitheliocytes, the patients' age.

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Peptic Ulcer

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Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...