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Related Concept Videos

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Related Experiment Video

Updated: Apr 10, 2026

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
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Lensless phase microscopy and diffraction tomography with multi-angle and multi-wavelength illuminations using a LED

Chao Zuo, Jiasong Sun, Jialin Zhang

    Optics Express
    |June 16, 2015
    PubMed
    Summary
    This summary is machine-generated.

    We developed a compact, lensless imaging platform using a CMOS sensor and LED matrix for high-resolution, depth-resolved imaging. This cost-effective device enables advanced diagnostics in remote settings.

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    Area of Science:

    • Optics and Photonics
    • Biomedical Imaging
    • Microscopy

    Background:

    • Traditional microscopy often requires bulky and expensive components.
    • Lensless imaging techniques offer potential for miniaturization and cost reduction.
    • Quantitative phase imaging and diffraction tomography provide rich contrast and depth information.

    Purpose of the Study:

    • To develop a compact, on-chip lensless imaging platform.
    • To achieve high-quality, depth-resolved imaging using multi-wavelength phase retrieval and multi-angle illumination diffraction tomography.
    • To demonstrate the platform's utility for biological sample imaging and its potential for telemedicine.

    Main Methods:

    • Utilized a CMOS image sensor and a programmable color LED matrix.
    • Implemented multi-wavelength phase retrieval for quantitative phase information.
    • Applied multi-angle illumination diffraction tomography for depth-resolved imaging.

    Main Results:

    • Achieved a lateral resolution of 3.72μm and an axial resolution of 5μm.
    • Covered a wide field-of-view of 24mm².
    • Successfully imaged cheek cells, micro-beads, and Parascaris equorum eggs.

    Conclusions:

    • The developed on-chip platform provides high-quality, depth-resolved imaging.
    • The miniaturized and cost-effective device is suitable for telemedicine and point-of-care diagnostics in resource-limited environments.
    • This technology offers a promising alternative to conventional microscopy for various applications.