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Gastric ulcer is accompanied by a decrease of epidermal growth factor in gastric juice and saliva.

G Hansen1, C Müller, P Sinha

  • 1Institut für klinische Chemie und Biochemie, Freie Universität Berlin, Universitätsklinikum Rudolf Virchow, F.R.G.

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
|September 1, 1989
PubMed
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Patients with gastric ulcers show significantly lower epidermal growth factor (EGF) levels in saliva and gastric juice compared to healthy individuals. This suggests a potential role for EGF in gastric ulcer pathogenesis.

Area of Science:

  • Gastroenterology
  • Biochemistry
  • Cell Biology

Background:

  • Epidermal growth factor (EGF) is crucial for maintaining gastrointestinal mucosa integrity.
  • Altered EGF levels are implicated in various gastrointestinal disorders.

Purpose of the Study:

  • To compare epidermal growth factor (EGF) concentrations in saliva and gastric juice of patients with gastric or duodenal ulcers and gastritis versus healthy controls.
  • To investigate the role of EGF in the pathogenesis of these conditions.

Main Methods:

  • Development and validation of a novel, sensitive, and specific enzyme-linked immunosorbent assay (ELISA) system for EGF measurement.
  • Quantification of EGF concentrations in saliva and gastric juice samples from patient cohorts and healthy controls.

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Main Results:

  • Gastric juice and saliva from patients with gastric ulcer exhibited significantly lower EGF concentrations compared to healthy controls (p < 0.01).
  • No significant difference in EGF concentrations or outputs was observed in gastric juice of patients with duodenal ulcer compared to healthy controls.

Conclusions:

  • Reduced epidermal growth factor (EGF) levels in gastric juice and saliva may be a contributing factor in the development of gastric ulcers.
  • EGF does not appear to play a similar role in the pathogenesis of duodenal ulcers based on these findings.