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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
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Magnetic susceptibility contrast variations in multiple sclerosis lesions
Xu Li1,2, Daniel M Harrison3, Hongjun Liu1,2,4
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Journal of Magnetic Resonance Imaging : JMRI
|June 16, 2015
Summary
Quantitative susceptibility mapping (QSM) and R2* mapping reveal diverse characteristics within multiple sclerosis (MS) lesions, aiding in a better understanding of MS pathology.
Area of Science:
- Neuroimaging
- Radiology
- Neurology
Background:
- Multiple sclerosis (MS) lesions exhibit heterogeneous magnetic susceptibility contrasts.
- Magnetic susceptibility measures, sensitive to iron and myelin, may better reflect MS lesion pathology.
Purpose of the Study:
- To characterize MS lesions using combined R2* mapping and quantitative susceptibility mapping (QSM).
- To investigate the relationship between R2* and susceptibility in different MS lesion types.
Main Methods:
- 306 MS lesions from 24 patients were analyzed using 7T MRI.
- R2*, frequency, and QSM maps were calculated from multiecho gradient echo data.
- Lesions were categorized by intensity and location; R2* and susceptibility values were quantified and compared.
Main Results:
- While most lesions (93%) were hypointense on R2*, susceptibility contrast varied: 40% isointense, 58% hyperintense.
- Significant correlation between R2* and susceptibility found in hyperintense lesions (r=0.31, P<0.001).
- Periventricular lesions showed a higher proportion of hyperintensity (74%) compared to subcortical (53%) and juxtacortical (38%) lesions.
Conclusions:
- Combined R2* and QSM effectively characterize the heterogeneity of MS lesions.
- These techniques offer valuable insights into the pathological features of MS lesions.
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