Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026

Same author

Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins.

European journal of immunology·2025

Same author

Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy.

Nature communications·2025

Same author

Aryl hydrocarbon receptor restrains tonic cytokine responses by inhibiting microbiota sensing in monocytes.

The Journal of clinical investigation·2025

Same author

Monocyte-Derived Dendritic Cells: An Updated View on an Old Concept.

Immunological reviews·2025

Same author

Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Apr 10, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Cross-Presentation in Mouse and Human Dendritic Cells.

Elodie Segura¹, Sebastian Amigorena¹

¹Institut Curie, Paris Cedex 05, France; INSERM U932, Paris Cedex 05, France.

Advances in Immunology

|June 16, 2015

Summary

Cross-presentation, vital for cytotoxic immune responses, involves exogenous antigens on MHC class I molecules. Dendritic cells (DCs) are key, with research exploring their mechanisms, subsets, and roles in disease.

Keywords:

Cross-presentation DC subsets Dendritic cells Human Phagosome

More Related Videos

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Related Experiment Videos

Last Updated: Apr 10, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Area of Science:

Immunology
Cell Biology

Background:

Cross-presentation is the process of displaying external antigens via MHC class I molecules.
This mechanism is crucial for initiating cytotoxic T cell responses.
Dendritic cells (DCs) are recognized as the primary cells responsible for cross-presentation.

Purpose of the Study:

To review recent advancements in understanding the molecular mechanisms of cross-presentation.
To detail the distinct dendritic cell subsets in mice and humans.
To summarize the functional specialization of these DC subsets in cross-presentation and their role in pathology.

Main Methods:

Literature review of recent research on cross-presentation.
Analysis of studies identifying and characterizing dendritic cell subsets.
Synthesis of information on the functional roles of DCs in immune responses and disease.

Main Results:

Dendritic cells are central to initiating cytotoxic immune responses through cross-presentation.
Specific DC subsets exhibit specialized functions in cross-presentation.
Cross-presentation plays a significant role in various pathological conditions.

Conclusions:

Understanding the molecular mechanisms and DC subsets involved in cross-presentation is advancing.
The specialized functions of DC subsets are critical for effective immune surveillance and response.
Further research into cross-presentation is essential for understanding and potentially treating diseases.