Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Anti-ulcer effect of extract from phellodendri cortex].

T Uchiyama, H Kamikawa, Z Ogita

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan

|September 1, 1989

Summary

A berberine-free extract from Phellodendri Cortex demonstrates significant anti-ulcer activity. This fraction protects against various induced ulcers and reduces gastric acid secretion in animal models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kupffer cell-mediated inhibition of liver regeneration after combined hepatectomy and pancreatectomy.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·1999

Same author

Responses of Mentha suspension-cultured cells to 2,4-dichlorophenoxyacetic acid and accumulation of esterified phenolic acids in their cell walls.

Bioscience, biotechnology, and biochemistry·1999

Same author

Microstructure of the trabecula and cortex of iliac bone in primary hyperparathyroidism patients determined using histomorphometry and node-strut analysis.

Journal of bone and mineral metabolism·1999

Same author

Graphical comparison of coronary arterial culprit lesions in acute myocardial infarction and unstable angina pectoris.

Internal medicine (Tokyo, Japan)·1999

Same author

Hyperalgesic response to noxious stimulation in genetically polydipsic mice.

Brain research·1999

Same author

Double-layered membrane vesicles released from mammalian cells infected with Sendai virus expressing the matrix protein of vesicular stomatitis virus.

Virology·1999

Area of Science:

Pharmacology
Gastroenterology
Traditional Chinese Medicine

Background:

Phellodendri Cortex (Phellodendron amurense Ruprecht) is a traditional Chinese medicine used for gastrointestinal ailments.
Berberine, a key component, exhibits various biological activities, including anti-inflammatory effects.
Previous research indicated anti-inflammatory properties in a berberine-free fraction of Phellodendri Cortex extract.

Purpose of the Study:

To investigate the anti-ulcer activity of the berberine-free fraction of Phellodendri Cortex extract.
To determine the mechanisms underlying the observed anti-ulcer effects, including effects on gastric acid secretion.

Main Methods:

The berberine-free fraction was tested for its ability to inhibit ethanol-induced, aspirin-induced, pylorus-ligated, and stress-induced ulcers in rats and mice.
Gastric acid secretion was measured in pylorus-ligated rats following administration of the fraction via subcutaneous, intraduodenal, and oral routes.

Main Results:

The berberine-free fraction significantly inhibited the formation of ethanol-induced, aspirin-induced, pylorus-ligated, and stress ulcers.
Gastric acid secretion was significantly reduced in pylorus-ligated rats after subcutaneous or intraduodenal administration of the fraction.
Oral administration of the fraction did not significantly affect gastric acid secretion.

Conclusions:

The berberine-free fraction of Phellodendri Cortex extract possesses significant anti-ulcer properties.
The anti-ulcer effects are likely due to a combination of cytoprotection and the reduction of gastric acid secretion.
This fraction represents a potential therapeutic agent for peptic ulcer disease.

Related Experiment Videos