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Lower extremity peripheral vascular disease. Part 1: Scanning electron microscopy
Journal of the American Podiatric Medical Association
|November 1, 1989
Summary
Podiatric surgeons strive to save limbs from amputation due to peripheral vascular disease. However, advanced vascular disease can necessitate extremity amputation, prompting this study of associated blood vessel tissue alterations.
Area of Science:
- Vascular Surgery
- Podiatric Medicine
- Pathology
Background:
- Peripheral vascular disease (PVD) poses a significant risk to limb viability.
- Podiatric surgeons prioritize limb salvage, resisting surgical amputation.
- Advanced PVD can lead to situations where amputation is the only viable option.
Purpose of the Study:
- To assess extremity amputations in patients with advanced peripheral vascular disease.
- To investigate the specific tissue alterations present in diseased blood vessels contributing to amputation.
Main Methods:
- Examination of gross pathological findings in amputated extremities.
- Utilizing scanning electron microscopy to analyze microstructural changes in diseased blood vessels.
Main Results:
- Detailed gross pathological descriptions of affected tissues were recorded.
- Scanning electron microscopy revealed specific ultrastructural alterations in the implicated blood vessels.
Conclusions:
- This study provides insights into the pathological vascular changes leading to amputation.
- Understanding these alterations is crucial for improving limb salvage strategies in PVD patients.
- This research serves as the foundational part of a two-part investigation.