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Microvesicles: What is the Role in Multiple Sclerosis?

Tiziana Carandini1, Federico Colombo1, Annamaria Finardi1

  • 1Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute , Milan , Italy.

Frontiers in Neurology
|June 16, 2015
PubMed

Insights

Microvesicles from immune cells like microglia and macrophages may drive multiple sclerosis (MS) inflammation and neuronal damage. These microvesicles are potential biomarkers and therapeutic targets for MS.

Area of Science:

  • Cellular Biology
  • Neuroscience
  • Immunology

Background:

  • Microvesicles mediate cell communication and are implicated in neuroinflammation.
  • Their role in multiple sclerosis (MS) pathogenesis is largely unknown.
  • Pro-inflammatory microglia and macrophages release microvesicles that spread inflammation.

Purpose of the Study:

  • To review the role of microvesicles in MS pathogenesis.
  • To focus on microglia and macrophage-derived microvesicles in MS.
  • To explore microvesicles as potential MS biomarkers and therapeutic targets.

Main Methods:

  • Literature review
  • Analysis of existing evidence on microvesicles in MS
  • Focus on microglia and macrophage roles

Main Results:

  • Microvesicles from microglia and macrophages contribute to MS pathogenesis.
  • These microvesicles spread inflammatory signals.
  • They alter neuronal functions, contributing to disease progression.

Conclusions:

  • Microvesicles, particularly from microglia and macrophages, play a significant role in MS.
  • They represent promising biomarkers for MS diagnosis and prognosis.
  • Targeting these microvesicles offers a potential therapeutic strategy for MS.
Keywords:
biomarkersectosomesexosomeshorizontal communicationmicrogliamicrovesiclesmultiple sclerosis

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