Related Experiment Video

Updated: Apr 10, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

11.0K

Estrogen-Related Receptors in Breast Cancer and Prostate Cancer

Aya Misawa1, Satoshi Inoue2

  • 1Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.

Frontiers in Endocrinology
|June 16, 2015
PubMed

Insights

Estrogen-related receptors (ERRs) are key in hormone-dependent cancers like breast and prostate cancer. Understanding their role offers new therapeutic targets for treatment-resistant malignancies.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Estrogen-signaling pathways are crucial in breast and prostate cancer development.
  • Estrogen-related receptors (ERRs) represent alternative pathways, distinct from classical estrogen receptors (ERs).
  • ERRs are constitutively active and do not bind estrogen, unlike ERs.

Purpose of the Study:

  • To review the structural features of ERRs.
  • To elucidate the involvement of each ERR in breast and prostate cancer.
  • To highlight ERRs as potential therapeutic targets for hormone-dependent cancers.

Main Methods:

  • Literature review focusing on structural characteristics of ERRs.
  • Analysis of studies investigating ERR roles in breast and prostate cancer.
  • Synthesis of current knowledge on ERR involvement in these malignancies.

Main Results:

  • ERRs are homologous to ERs but function independently of estrogen.
  • ERRs are implicated in alternative oncogenic pathways in breast and prostate cancer.
  • Specific roles of individual ERRs in these cancers are being elucidated.

Conclusions:

  • ERRs are significant players in hormone-dependent cancers.
  • Targeting ERRs may offer novel treatment strategies for refractory breast and prostate cancers.
  • Further research into ERR pathways is critical for therapeutic development.
Keywords:
androgenbreast cancerestrogenestrogen receptorsestrogen-related receptorsprostate cancer

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.8K
An Ex vivo Model to Study Hormone Action in the Human Breast12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

12.1K

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
6.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.5K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
5.0K
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
63.1K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
76.7K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
6.5K