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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Related Experiment Video

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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Allergic Rhinitis: an Overview.

Jitendra Varshney1, Himanshu Varshney2

  • 1Pharmacy In CHARGE, Sri Sai Hospital, Delhi Road, Moradabad, 244001 U.P. India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|June 16, 2015
PubMed
Summary
This summary is machine-generated.

Allergic rhinitis, an IgE-mediated nasal inflammation, affects 20-30% of Indians. Effective treatment combines allergen avoidance, pharmacotherapy, and immunotherapy, with intranasal corticosteroids being most effective.

Keywords:
Allergic rhinitisAsthmaImmunotherapyIntranasal corticosteroid

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Area of Science:

  • Immunology
  • Otolaryngology
  • Allergology

Background:

  • Allergic rhinitis is a common inflammatory nasal disorder triggered by allergens, leading to symptoms like rhinorrhea, sneezing, itching, and congestion.
  • It frequently co-exists with other conditions such as asthma, atopic dermatitis, and nasal polyps.
  • Prevalence in India is high, with 20-30% affected by allergic rhinitis and 15% developing asthma.

Purpose of the Study:

  • To outline the diagnostic and treatment strategies for allergic rhinitis.
  • To emphasize the importance of adhering to established guidelines like ARIA and GINA.
  • To highlight effective treatment modalities and factors influencing patient compliance.

Main Methods:

  • Diagnosis and treatment align with Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines.
  • Asthma management follows Global Initiative for Asthma (GINA) guidelines.
  • Treatment strategies integrate allergen avoidance, pharmacotherapy, and allergen immunotherapy.

Main Results:

  • Intranasal corticosteroids are identified as the most effective treatment for allergic rhinitis.
  • Sensory attributes of intranasal corticosteroids play a crucial role in patient compliance.
  • The comprehensive approach addresses both allergic rhinitis and its associated comorbidities.

Conclusions:

  • Adherence to ARIA and GINA guidelines is crucial for optimal patient outcomes.
  • A multi-modal treatment approach including allergen avoidance, pharmacotherapy, and immunotherapy is recommended.
  • Optimizing intranasal corticosteroid formulations can enhance patient compliance and treatment efficacy.