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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Diabetes and stem cell function.
Shin Fujimaki1, Tamami Wakabayashi2, Tohru Takemasa3
1Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-4 Higashi, Tsukuba, Ibaraki 305-8562, Japan ; Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Biomed Research International
|June 16, 2015
Summary
Physical activity can prevent diabetes-related damage to nerve and muscle tissues by improving stem cell function. This approach enhances physiological functions and quality of life for individuals with diabetes.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Neuroscience
- Regenerative Medicine
Background:
- Diabetes mellitus is a prevalent metabolic disorder characterized by hyperglycemia.
- Diabetic complications affect neuronal tissues and skeletal muscle, impacting stem cell function.
- Nervous disorders and muscle atrophy are significant consequences of diabetes.
Purpose of the Study:
- To review alterations in diabetic neuronal and skeletal muscle tissues, focusing on stem cells.
- To examine the preventive effects of physical activity on these diabetic complications.
- To discuss stem cell-based treatments for diabetes.
Main Methods:
- Literature review of studies on diabetes, stem cells, and physical activity.
- Analysis of the impact of diabetes on neural stem cells and satellite cells.
- Evaluation of physical activity's role in mitigating diabetic tissue damage.
Main Results:
- Diabetes impairs neural stem cell function, contributing to cognitive deficits and neurological disorders.
- Diabetic skeletal muscle exhibits atrophy, impaired metabolism, and reduced satellite cell activity.
- Physical activity enhances neurogenesis and improves satellite cell proliferation and differentiation.
Conclusions:
- Physical activity is a beneficial intervention for preventing and managing diabetic complications in neuronal and skeletal muscle tissues.
- Regular exercise can restore physiological functions and improve the quality of life for diabetic patients.
- Stem cell-based therapies hold promise for future diabetes treatment strategies.
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