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Monoclonal antibodies and thromboembolism
1State University of New York Health Science Center, University Hospital, Syracuse 13210.
Journal of Thoracic Imaging
|October 1, 1989
Summary
Radionuclide imaging of thrombi has improved with monoclonal antibodies targeting platelets or fibrin. These show promise in clinical trials for detecting blood clots in various locations.
Area of Science:
- Nuclear medicine
- Immunology
- Cardiovascular research
Background:
- Historically, radionuclide techniques for thrombus imaging were unreliable.
- Recent advancements involve monoclonal antibodies targeting specific thrombus components.
Purpose of the Study:
- To evaluate the efficacy of monoclonal antibodies for thrombus imaging.
- To explore the potential of radiolabeled antibody technology for detecting thrombi in diverse anatomical locations.
Main Methods:
- Development of monoclonal antibodies against platelet antigens and fibrin polymer.
- Experimental animal studies and clinical trials of antibody-based imaging agents.
Main Results:
- Monoclonal antibodies have emerged as potent thrombus imaging agents in animal models.
- Successful clinical trials of antiplatelet antibodies in Britain and antifibrin antibodies in the US.
Conclusions:
- Radiolabeled antibody technology holds significant promise for improved thrombus detection.
- Further evolution of this technology may enable detection of thrombi in the lungs and brain.
- The comparative effectiveness of radionuclide imaging versus Doppler ultrasonography for thrombus detection remains undetermined.