Morbidity and mortality of bacterial meningitis in Arab children

A A Shaltout1, L T Auger, N B Awadallah

  • 1Department of Pediatrics, Faculty of Medicine, University of Kuwait.

The Journal of Tropical Medicine and Hygiene
|December 1, 1989
PubMed

Insights

Bacterial meningitis in Kuwaiti children was primarily caused by Haemophilus influenzae. While overall fatality was low, Streptococcus pneumoniae infections led to more severe neurological complications.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Bacterial meningitis remains a significant cause of childhood morbidity and mortality globally.
  • Understanding the etiological agents and outcomes of bacterial meningitis is crucial for public health interventions.

Purpose of the Study:

  • To investigate the epidemiological characteristics, causative agents, and clinical outcomes of bacterial meningitis in children treated in Kuwait.

Main Methods:

  • Retrospective analysis of 92 episodes of bacterial meningitis in 90 children treated between September 1981 and March 1987.
  • Bacteriological confirmation of diagnosis and identification of causative organisms.
  • Assessment of case fatality rates and neurological sequelae.

Main Results:

  • Haemophilus influenzae was the most frequent pathogen (45.6%), followed by Streptococcus pneumoniae (22.8%).
  • The majority of cases (88%) occurred in children under 5 years of age.
  • The overall case fatality rate was 5.4%, with 9% experiencing severe neurological sequelae, which were more common after pneumococcal meningitis.

Conclusions:

  • Haemophilus influenzae is the leading cause of bacterial meningitis in Kuwaiti children.
  • Prompt diagnosis and treatment are essential to reduce mortality and long-term neurological deficits.
  • Further research into prevention strategies, such as vaccination, is warranted.

Related Concept Videos

Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...