Related Experiment Video For Cervical melanoma
Updated: Apr 10, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Primary gynecologic melanoma: A report of two unusual cases
Jessica L Berger1, Daman Samrao2, Marilyn Huang1
1Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Background:
Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically.
Cases:
A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab.
Conclusion:
Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
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