[The significance of lipid peroxidation (free radical) on hepatocellular dysfunction following hepatectomy]

The possibility of extended hepatectomy was examined clinically and experimentally, with special reference to relation between remnant liver dysfunction and lipid peroxidation. Clinical study: When the functional reserve of the remnant liver prior to hepatectomy was below the critical level, both serum phospholipase A2 and plasma lipid peroxide increased and severe hepatic insufficiency occurred. Experimental study in dogs: The amount of lipid peroxide in the plasma and remnant liver increased more after 84% hepatectomy than after 70% hepatectomy, causing significant impairment of the remnant liver function. To prevent hepatic dysfunction after hepatectomy, Coenzyme Q10, an antioxidant and a membrane stabilizer, were administered. These substances reduced the increase of lipid in the plasma and remnant liver, and restored the liver function with subsequent good regeneration. The results suggest that the administration of Coenzyme Q10 may be useful for recovery of liver function and a more favorable prognosis following the extended hepatectomy.