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Published on: August 15, 2019
Genetic ME-a visualization application for merging and editing pedigrees for genetic studies
Diem K Bui1, Yingda Jiang2, Xin Wei3
1Department of Ophthalmology, David Geffen School of Medicine-UCLA, Los Angeles, CA, 90095, USA. diem.k.bui@gmail.com.
Genetic ME software merges pedigree data from multiple sources, reconciling discrepancies for accurate genetic studies. This tool tracks changes and visualizes unified family structures for further analysis.
Area of Science:
- Genetics
- Bioinformatics
- Computational Biology
Background:
- Studying disease genetics requires accurate family pedigrees.
- Multiple informants can provide conflicting pedigree data.
- Software is needed to unify disparate pedigree information.
Purpose of the Study:
- To develop software for reconciling and merging pedigree data from multiple sources.
- To create a unified pedigree structure from independent collections.
Main Methods:
- Developed Genetic Merging & Editing (Genetic ME) program.
- An open-source Java application utilizing CraneFoot and Ghostscript.
- Features a visually-oriented interface for comparing, editing, and merging pedigrees.
Main Results:
- Genetic ME successfully merges pedigree data by adding, replacing, and combining information.
- A tracking process allows tracing all data changes to their original sources.
- The software visualizes new pedigree structures from reconciled data.
Conclusions:
- Genetic ME is a valuable addition for reconciling pedigree information.
- It offers a user-friendly interface, tracks user changes, and generates usable merged structures.
- The software supports further analysis by other popular programs.
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