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Updated: Apr 10, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Lymph node density as an independent prognostic factor in node-positive patients with tonsillar cancer
Jun-Ook Park1, Young-Hoon Joo2, Kwang-Jae Cho2
1Department of Otolaryngology - Head and Neck Surgery, Inje University College of Medicine, Haeundae Paik Hospital, Busan, South Korea.
Background:
The purpose of this study was to evaluate the utility of lymph node density for predicting the survival of patients with tonsillar cancer and positive neck nodes.
Methods:
We reviewed data for 64 patients diagnosed with tonsillar cancer with lymph node metastasis in a retrospective single center audit.
Results:
Lymph node density (≥0.05), extracapsular spread (ECS), number of ECS (≥3), vascular invasion, perineural invasion, and N classification (N1/N2a vs N2b/N2c) were significant predictors of 5-year disease-free survival (DFS). Lymph node density (≥0.05), human papillomavirus (HPV) infection, and N classification (N1/N2a vs N2b/N2c) were significant predictors of 5-year overall survival (OS). In the multivariate analysis, categorical lymph node density remained a significant predictor of DFS (p = .025*; hazard ratio [HR] = 6.063) and no parameter was significantly predictive of OS.
Conclusion:
Lymph node density might be useful as an independent predictor of survival in patients with tonsillar cancer and positive lymph nodes. © 2015 Wiley Periodicals, Inc. Head Neck 38: E705-E711, 2016.
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