[Effect of enteric nervous system on anti-peristaltic discharge]

The mechanism of the occurrence of anti-peristaltic discharge originated in the stomach distal to the transection followed by end-to-end anastomosis has not been elucidated. The purpose of this study is to investigate the effect of the enteric nervous system on the anti-peristaltic discharge in the canine stomach distal to the transection by using sodium channel blocking agent TTX and ganglion blocking agent C6 together with local anesthetic lidocaine electromyographycally. Following results were obtained. 1. The retardation of propagation velocity of normo-peristaltic discharge and the decrease of frequency of anti-peristaltic discharge were noted both at TTX 10 micrograms/kg iv. and TTX 10 micrograms/kg iv. together with mucosal anesthetization by lidocaine. And no significant difference was recognized between them. 2. The retardation of propagation velocity of normo-peristaltic discharge and the decrease of frequency of anti-peristaltic discharge were noted at C6 10 mg/kg iv. together with mucosal anesthetization by lidocaine. While the decrease of frequency of anti-peristaltic discharge was only noted at C6 10 mg/kg iv. Conclusively, it was suggested that the nervous pathway which transmits some excitive information from mucosa to the myenteric plexus exists and that the myenteric plexus has a important role on the occurrence of anti-peristaltic discharge.