Related Experiment Video
Updated: Apr 10, 2026
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Differences Between Vascular Structural Abnormality and Hypertensive Intracerebral Hemorrhage
Chunyan Lei1, Bo Wu1, Ming Liu1
1Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P. R. China.
Insights
Patients with vascular structural abnormality-related intracerebral hemorrhage (ICH) have better outcomes than those with hypertensive ICH. Etiology, age, Glasgow Coma Scale (GCS) score, and hematoma volume predict ICH outcomes.
Area of Science:
- Neurology
- Neurosurgery
- Vascular Medicine
Background:
- The clinical characteristics and prognosis of vascular structural abnormality-related intracerebral hemorrhage (ICH) compared to hypertensive ICH are not well understood.
- This knowledge gap complicates differential diagnosis and prognosis prediction.
Purpose of the Study:
- To compare the clinical characteristics and prognosis of vascular structural abnormality-related ICH versus hypertensive ICH.
- To identify independent predictors of mortality and good outcome following ICH.
Main Methods:
- A prospective cohort study enrolled 281 patients with ICH from 50 hospitals in China.
- Patients were categorized into vascular structural abnormality-related ICH or hypertensive ICH groups.
- Demographics, clinical characteristics, and outcomes were compared using multivariate logistic regression.
Main Results:
- Vascular structural abnormality-related ICH occurred in younger patients with higher Glasgow Coma Scale (GCS) scores, primarily in lobar areas.
- Mortality at 3 months was significantly lower (3.4% vs. 15.2%) and good outcomes significantly higher (77.2% vs. 49.9%) in the vascular structural abnormality-related ICH group (P < .001).
- Independent predictors of mortality included lower GCS score, older age, intraventricular hemorrhage, larger hematoma volume, and surgery; predictors of good outcome included vascular structural abnormality etiology, higher GCS score, younger age, and smaller hematoma volume.
Conclusions:
- Patients with vascular structural abnormality-related ICH generally experience better clinical outcomes compared to those with hypertensive ICH.
- ICH etiology, GCS score, age, and hematoma volume are key independent predictors of patient outcomes.
Background:
How the clinical characteristics and prognosis of various types of vascular structural abnormality-related intracerebral hemorrhage (ICH) differ from those of hypertensive ICH is poorly understood. This lack of understanding poses a problem for differential diagnosis and prognosis.
Methods:
Patients diagnosed with ICH between January 2012 and February 2014 at 50 tertiary and secondary hospitals in China were enrolled into this prospective cohort study. Patients were classified as having vascular structural abnormality-related ICH or hypertensive ICH, and data on the demographics and clinical characteristics of each group were compared. Multivariate logistic regression was used to explore associations while controlling for other risk factors for good outcome and mortality.
Results:
Data for 281 patients showed that vascular structural abnormality-related ICH usually occurred in lobar areas and affected patients who were younger and had higher Glasgow Coma Scale (GCS) scores than those with hypertensive ICH. Mortality and good outcome at 3 months after ICH were significantly better among patients with vascular structural abnormality-related ICH (3.4% and 77.2%) than among patients with hypertensive ICH (15.2% and 49.9%, both P < .001). Multivariate logistic regression identified the following independent predictors of mortality: lower GCS score, old age, presence of intraventricular hemorrhage, larger hematoma volume, and surgery treatment. The regression also identified several independent predictors of good outcome at 3 months: ICH etiology due to vascular structural abnormality, higher GCS score, younger age, and smaller hematoma volume.
Conclusions:
Patients with vascular structural abnormality-related ICH are more likely to experience better clinical outcomes than those with hypertensive ICH. GCS score, age, hematoma volume, and ICH etiology are independent predictors of ICH outcome.
