Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Molecule methods to investigate mechanisms of transcription by RNA polymerase of Mycobacterium tuberculosis.

Methods (San Diego, Calif.)·2026
Same author

KCMF1-mediated influenza A virus PB1 ubiquitination at K653 regulates viral replication.

Journal of virology·2026
Same author

Elucidating the role of Toxoplasma gondii EF-hand containing protein 1 in parasite biology and its potential as a subunit vaccine antigen.

Acta tropica·2026
Same author

Quaternary Ammonium-Cu<sub>2</sub>O Nanocomposite with Synergistic Multimode Antibacterial Action for Eradicating MRSA and Mitigating Resistance Development.

ACS applied bio materials·2026
Same author

LEP Knockdown Improves Functional Recovery After Spinal Cord Injury and Potentially Regulates Microglial Polarization via JAK-STAT Signaling Pathway.

Neuromolecular medicine·2026
Same author

Carbon-induced multiscale coupling mechanisms of chlorine release and heavy metal migration during thermal treatment of MSWI fly ash.

Journal of hazardous materials·2026
Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026
Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026
Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026
Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026
Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Apr 10, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.9K

Tip-multi-breaking in Capillary Microfluidic Devices.

Pingan Zhu1, Tiantian Kong1, Zhanxiao Kang1

  • 11] Department of Mechanical Engineering, the University of Hong Kong, Hong Kong [2] HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), 311300, Hangzhou, Zhejiang, China.

Scientific Reports
|June 17, 2015
PubMed
Summary
This summary is machine-generated.

We discovered a new tip-multi-breaking (TMB) mode in microfluidic droplet breakup. This controlled droplet formation offers unique geometric properties for applications like data encryption and anti-fake identification.

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

22.0K
High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

14.3K

Related Experiment Videos

Last Updated: Apr 10, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.9K
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

22.0K
High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

14.3K

Area of Science:

  • Fluid Dynamics
  • Microfluidics
  • Nonlinear Dynamics

Background:

  • Droplet breakup in microfluidic devices is crucial for various applications.
  • Understanding different breakup modes is essential for controlling droplet generation.

Purpose of the Study:

  • To report and characterize a novel tip-multi-breaking (TMB) mode of droplet breakup.
  • To define the parameter space for the TMB mode.
  • To explore the potential applications of the unique droplet morphology generated by TMB.

Main Methods:

  • Experimental investigation of droplet breakup in capillary microfluidic devices.
  • Systematic variation of inner and outer fluid capillary numbers (Cai and Ca0).
  • Analysis of droplet formation dynamics, pinch-off times, and droplet sizes.

Main Results:

  • The tip-multi-breaking (TMB) mode was identified within a specific region of the Cai-Ca0 phase diagram.
  • TMB is characterized by periodic, constant-speed thinning of the inner liquid tip, forming sequences of droplets.
  • The number of droplets in a sequence increases with the outer phase capillary number (Ca0).
  • Droplet pinch-off times and sizes follow a geometric progression, with the ratio dependent on the droplet number (n).

Conclusions:

  • The TMB mode presents a unique mechanism for generating ordered droplet sequences.
  • The predictable geometric progression of droplet characteristics is a key feature of TMB.
  • The distinct geometric morphology of TMB-generated droplet clusters holds promise for encryption and anti-fake identification technologies.