Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.9K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.9K
Infertility in Males01:23

Infertility in Males

502
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
502
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
Menopause01:28

Menopause

3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

419
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
419
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

531
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
531

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case - Artificial urinary sphincter pressure-regulating balloon perforation following increased intra-abdominal pressure.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2026
Same author

GreenLight laser prostatectomy: Are outcomes sustainable after a decade of surgery? A single-center experience with up to 15 years' followup.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2025
Same author

Predicting poor early voiding pattern after holep using maximum flow rate (Q-max) as an objective outcome.

World journal of urology·2025
Same author

The hormonal regulation of men's sexual desire, arousal, and penile erection: recommendations from the fifth international consultation on sexual medicine (ICSM 2024).

Sexual medicine reviews·2025
Same author

Modified early apical release vs. non-early apical release in holmium laser prostatic enucleation Impact on stress urinary incontinence.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2025
Same author

Reply to Chi-Wen Lo, Shen Shiou Tseng, and Yao-Chou Tsai's Letter to the Editor re: Tarek Benzouak, Abdulmalik Addar, Michael A. Prudencio-Brunello, et al. Comparative Analysis of Holmium Laser Enucleation of the Prostate (HoLEP) and Robotic-Assisted Simple Prostatectomy (RASP) in BPH Management: A Systematic Review and Meta-Analysis. J Urol. In press. https://doi.org/10.1097/JU.0000000000004297.

European urology focus·2025

Related Experiment Video

Updated: Jan 6, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.3K

Update on Testosterone Replacement Therapy in Hypogonadal Men.

Kevin Matthew Yen Bing Leung1, Khalid Alrabeeah, Serge Carrier

  • 1McGill University, 9D-1210 Boulevard de Maisonneuve Ouest, Montreal, QC, H3A0A2, Canada, Kevin.Leung@mail.mcgill.ca.

Current Urology Reports
|June 17, 2015
PubMed
Summary

Testosterone replacement therapy (TRT) is a treatable option for late-onset male hypogonadism. This review clarifies TRT indications, formulations, and addresses controversies regarding prostate, cardiovascular, and sexual health.

More Related Videos

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.8K
Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.6K

Related Experiment Videos

Last Updated: Jan 6, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.3K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.8K
Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.6K

Area of Science:

  • Endocrinology
  • Urology
  • Men's Health

Background:

  • Late-onset male hypogonadism is a recognized condition.
  • Misconceptions have limited the mainstream use of testosterone replacement therapy (TRT).

Purpose of the Study:

  • To provide an updated understanding of TRT.
  • To guide clinicians on patient selection and treatment protocols.
  • To analyze current literature on TRT controversies.

Main Methods:

  • Literature review of current understanding of TRT.
  • Analysis of various TRT formulations, including risks and benefits.
  • Comprehensive review of controversies surrounding TRT.

Main Results:

  • TRT is indicated for specific patient populations with hypogonadism.
  • Different TRT formulations offer varied risk-benefit profiles.
  • TRT's impact on prostate, cardiovascular, sexual health, frailty, and mood is debated.

Conclusions:

  • TRT is a viable treatment for late-onset male hypogonadism when appropriately indicated.
  • Understanding TRT formulations and potential risks is crucial for safe and effective treatment.
  • Further research is needed to fully elucidate TRT's long-term effects and address ongoing controversies.