Related Experiment Video
Updated: Apr 10, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
15.1K
Orbital lymphaticovenous malformations: Current and future treatments
Nariman Nassiri1, Jack Rootman1, Daniel B Rootman1
1Division of Orbital and Ophthalmic Plastic Surgery, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Survey of Ophthalmology
|June 17, 2015
Summary
Orbital lymphaticovenous malformations are complex vascular anomalies requiring multidisciplinary management. Future targeted therapies are needed to address their heterogeneous nature and reduce recurrence.
Area of Science:
- Ophthalmology
- Vascular Biology
- Regenerative Medicine
Background:
- Orbital lymphaticovenous malformations (LVMs) are complex vascular anomalies with mixed venous and lymphatic characteristics.
- These lesions pose significant management challenges due to incomplete excision and high recurrence rates.
Purpose of the Study:
- To review the current understanding and management of orbital LVMs.
- To highlight the need for novel therapeutic strategies, including targeted biologic therapies.
Main Methods:
- Literature review of orbital lymphaticovenous malformations.
- Analysis of current surgical and nonsurgical treatment modalities.
- Discussion of potential future therapeutic targets.
Main Results:
- Orbital LVMs exhibit diverse venous and lymphatic endothelial cell characteristics.
- Current treatments like surgery, sclerosants, and liquid polymers have limitations.
- Recurrence is common, and interventions risk damaging adjacent structures.
Conclusions:
- A multidisciplinary approach combining surgical and nonsurgical methods is currently recommended for orbital LVMs.
- Development of targeted antiangiogenic therapies is crucial for effective treatment and reduced regrowth.
- Further research into the angiogenic activities and marker expression profiles of these lesions is warranted.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:28Angle Closure Glaucoma: Treatment
1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
01:16Lymphatic Vessels and Lymph Transport
24.8K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
24.8K
01:15Development of the Lymphatic System
2.7K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.7K