Bilateral diffuse uveal melanocytic proliferation with mucocutaneous pigmentation

Area of Science:

• Ophthalmology
• Oncology
• Dermatology

Background:

• Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome.
• It is typically associated with various extraocular malignancies.
• Previous reports have noted the presence of extraocular pigmented lesions in some cases.

Observation:

• Two patients diagnosed with BDUMP were observed.
• These patients presented with distinct non-ocular pigmented lesions.
• The non-ocular lesions were a notable feature in their clinical presentation.

Findings:

• The study highlights a previously under-recognized association between BDUMP and non-ocular pigmented lesions.
• This expands the spectrum of clinical manifestations for this rare syndrome.
• The findings suggest a potential link between the underlying malignancy and widespread melanocytic changes.

Implications:

• Increased awareness of non-ocular pigmented lesions may aid in earlier diagnosis of BDUMP.
• This could lead to prompt identification and management of associated extraocular malignancies.
• Further research is warranted to understand the pathogenesis of these widespread pigmented lesions in BDUMP.