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Calibration of ion-selective microelectrodes: flow-system and analysis program for the IBM PC
A W Barolet1, R Andrews, M E Morris
1Department of Pharmacology, University of Toronto, Canada.
Journal of Neuroscience Methods
|December 1, 1989
Summary
A new C and Assembly program for IBM PCs calibrates ion-selective microelectrodes, offering data analysis, curve fitting, and output options for enhanced electrochemical measurements.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Computer Science
Background:
- Ion-selective microelectrodes (ISMEs) are crucial for electrochemical measurements.
- Accurate calibration is essential for reliable ISME data.
- Manual calibration methods can be time-consuming and prone to error.
Purpose of the Study:
- To develop a user-friendly software for ISME calibration.
- To automate and improve the accuracy of ISME calibration processes.
- To provide comprehensive data analysis and reporting features.
Main Methods:
- A menu-driven program developed in C and Assembly language for IBM PC compatibles.
- Implementation of least squares non-linear regression for calibration curve fitting.
- Development of a flow system for rapid solution changes, with manual or computer control.
Main Results:
- The program facilitates rapid and accurate construction and display of calibration curves.
- Features include data analysis with drift correction and conversion to ion concentration/activity.
- Calculations of selectivity and activity coefficients are supported, with versatile data output.
Conclusions:
- The developed software offers a robust and efficient solution for ISME calibration.
- It enhances data accuracy and analysis capabilities for electrochemical research.
- The integrated system streamlines the workflow for ISME users.