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Stoppage in Autism Spectrum Disorders.

Therese K Grønborg¹, Stefan N Hansen², Svend V Nielsen³

¹Section for Biostatistics, Department of Public Health, Aarhus University, Bartholins Allé 2, 8000, Aarhus C, Denmark. therese@ph.au.dk.

Journal of Autism and Developmental Disorders

|June 17, 2015

Summary

Stoppage, or altered reproductive behavior after a child

Keywords:

Autism spectrum disorder Sibling recurrence risk Stoppage

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Area of Science:

Reproductive Epidemiology
Genetic Epidemiology
Autism Spectrum Disorders Research

Background:

Stoppage, defined as changes in reproductive behavior post-childbirth, can introduce bias in sibling recurrence risk estimates.
Differential stoppage, where it occurs non-randomly, poses a potential additional bias in these estimations.
Autism spectrum disorders (ASD) recurrence risk studies require careful consideration of such reproductive behavioral changes.

Purpose of the Study:

To investigate the occurrence of stoppage in Danish families with a firstborn child diagnosed with autism spectrum disorders.
To determine if stoppage in these families is differential (non-random).
To assess the impact of differential stoppage on sibling recurrence risk estimation for ASD in Denmark.

Main Methods:

Retrospective analysis of reproductive behavior in Danish families.
Statistical modeling to assess the presence and nature of stoppage.
Quantification of potential bias introduced by differential stoppage on sibling recurrence risk estimates for ASD.

Main Results:

Stoppage was found to occur moderately in Danish families affected by autism spectrum disorders.
The study confirmed that stoppage in this population is differential.
Differential stoppage was identified as a minor source of estimation bias in Danish sibling recurrence risk studies for ASD.

Conclusions:

Stoppage is a relevant factor in Danish families with a firstborn child diagnosed with ASD.
While differential stoppage occurs, its contribution to bias in sibling recurrence risk estimation for ASD is minimal.
Future recurrence risk studies in ASD should acknowledge and account for stoppage, though the impact of differential stoppage appears limited.