Stoppage in Autism Spectrum Disorders
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Updated: Apr 10, 2026

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
Published on: July 31, 2017
Therese K Grønborg1, Stefan N Hansen2, Svend V Nielsen3
1Section for Biostatistics, Department of Public Health, Aarhus University, Bartholins Allé 2, 8000, Aarhus C, Denmark. therese@ph.au.dk.
Abstract:
Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders.
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