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Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular

Shu-ichi Fujita1, Yoshihiro Takeda1, Shun Kizawa1

  • 1Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.

BMC Cardiovascular Disorders
|June 17, 2015
PubMed

Insights

Platelet indices like mean platelet volume (MPV) and platelet distribution width (PDW) are linked to heart conditions. Higher MPV and PDW levels correlate with left ventricular hypertrophy and dysfunction in cardiac patients.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are indicators of platelet activation.
  • Previous research has not fully elucidated the relationship between these platelet indices and cardiac structure/function.

Purpose of the Study:

  • To investigate the association between MPV and PDW and left ventricular hypertrophy (LVH).
  • To examine the relationship between MPV and PDW and left ventricular systolic and diastolic dysfunction.

Main Methods:

  • Analysis of data from 1241 patients admitted to a Cardiology Department.
  • Statistical analysis to identify independent factors associated with cardiac parameters.

Main Results:

  • Both MPV and PDW were independently associated with left ventricular hypertrophy, systolic dysfunction, and diastolic dysfunction.
  • The highest tertile of MPV was linked to a 1.53 odds ratio for systolic dysfunction.
  • The highest tertile of PDW showed associations with hypertrophy (OR 1.56) and dysfunction (OR 3.34).

Conclusions:

  • Platelet activation indices (MPV and PDW) are positively associated with left ventricular hypertrophy and dysfunction.
  • Further research is needed to determine if MPV and PDW can identify cardiac patients at higher risk for thromboembolic events or organ damage.
Abstract

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