Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.8K
Bacterial Transformation01:33

Bacterial Transformation

63.8K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
63.8K
Bacterial Transformation01:33

Bacterial Transformation

14.3K
14.3K
Bacterial Signaling01:30

Bacterial Signaling

43.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
43.5K
iChip01:24

iChip

77
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
77
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

147
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
147

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.

Oncoimmunology·2026
Same author

The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8<sup>+</sup> T cells.

EMBO reports·2026
Same author

Programmable DNA-Based Molecular Reservoir Biocomputing Network Circuits with Emerging Biomemristors for Solving Complex Nonlinear Problems.

ACS synthetic biology·2026
Same author

Pangenome dynamics and population structure of the zoonotic pathogen Salmonella enterica serotype Hadar.

Nature communications·2026
Same author

Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes.

Molecular systems biology·2026
Same author

Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes.

BMC microbiology·2025
Same journal

Inverse FIP effect plasma in the solar atmosphere: a synthesis of current understanding and new insights from AR 11967.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Signs of sulfur fractionation under high magnetic field strength.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

First ionization potential fractionation of sulfur observed with spectral imaging of the coronal environment.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Chromospheric dynamics and turbulence regulate the solar FIP effect.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Exploring the link between wave activity in the photospheric velocity driver and the FIP bias in the solar corona.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same journal

Radiative hydrodynamic simulations of first ionization potential fractionation in solar flares.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
See all related articles

Related Experiment Video

Updated: Apr 10, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

15.1K

Bacterial computing with engineered populations.

Martyn Amos1, Ilka Maria Axmann2, Nils Blüthgen3

  • 1School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, Manchester M1 5GD, UK m.amos@mmu.ac.uk.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|June 17, 2015
PubMed
Summary
This summary is machine-generated.

Researchers developed bacterial computing platforms using engineered bacteria. This involved creating intracellular circuits, single-cell interfaces, and cell-cell communication for complex computational tasks.

Keywords:
conjugationmathematical modellingsimulationsynthetic biologyunconventional computing

More Related Videos

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

13.3K
Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.8K

Related Experiment Videos

Last Updated: Apr 10, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

15.1K
Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

13.3K
Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.8K

Area of Science:

  • Synthetic Biology
  • Computational Biology
  • Microbial Engineering

Background:

  • Bacterial computing offers a novel platform for biological computation.
  • Engineered bacteria can be programmed to perform computational functions.

Purpose of the Study:

  • To outline strategies for constructing bacterial computing platforms.
  • To present results from the bacterial computing with engineered populations project.
  • To identify future research directions in bacterial computing.

Main Methods:

  • Development of intracellular genetic circuits for computation.
  • Implementation of single-cell input/output mechanisms.
  • Engineering of cell-cell communication interfaces.
  • Extensive computational and experimental analysis.

Main Results:

  • Demonstrated feasibility of bacterial computing platforms.
  • Successfully integrated key components: circuits, I/O, and communication.
  • Established a framework for bacterial computation.

Conclusions:

  • Bacterial computing platforms are achievable through integrated design.
  • Further research can expand the capabilities of these biological computers.
  • This work lays the foundation for advanced microbial computing systems.