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Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease

Branislav Milovanovic1, Branka Filipovic1, Slavica Mutavdzin1

  • 1Branislav Milovanovic, Slavica Mutavdzin, Tatjana Gligorijevic, Jovana Paunovic, Marina Arsic, Department of Cardiology, Neurocardiology Laboratory, Clinical and Hospital Center "Bezanijska Kosa", Belgrade 11080, Republic of Serbia.

World Journal of Gastroenterology
|June 17, 2015
PubMed

Insights

Gastroesophageal reflux disease (GERD) patients exhibit significant autonomic nervous system dysfunction, particularly impaired parasympathetic activity. This study highlights a strong link between GERD and autonomic imbalance.

Area of Science:

  • Cardiology
  • Neuroscience
  • Gastroenterology

Background:

  • Gastroesophageal reflux disease (GERD) is a common condition with potential systemic implications.
  • Autonomic nervous system (ANS) dysfunction has been implicated in various chronic diseases.

Purpose of the Study:

  • To investigate autonomic nervous system function in patients diagnosed with GERD.
  • To compare ANS parameters between GERD patients and healthy controls.

Main Methods:

  • The study included 29 GERD patients and 116 healthy volunteers.
  • Methods involved cardiovascular reflex testing, short-term and long-term heart rate variability (HRV) analysis, and 24-hour ambulatory blood pressure monitoring.

Main Results:

  • GERD patients showed significantly higher rates of abnormal cardiovascular reflex tests and severe autonomic dysfunction (44.4% vs 7.9%).
  • Reduced vagal activity (short-term HRV) and impaired parasympathetic function (long-term HRV, spectral analysis) were observed in GERD patients.
  • GERD patients exhibited higher systolic and pulse blood pressure compared to controls.

Conclusions:

  • Patients with GERD demonstrate altered sympathetic and parasympathetic ANS function.
  • Impaired parasympathetic nervous system activity is a prominent finding in GERD patients.
Abstract

Keywords:
Autonomic nervous systemBlood pressure monitoringCardiovascular reflex testECG monitoringGastroesophageal reflux disease

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