Related Experiment Video
Updated: Apr 10, 2026
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Sequential vs simultaneous revascularization in patients undergoing liver transplantation: A meta-analysis
Jia-Zhong Wang1, Yang Liu1, Jin-Long Wang1
1Jia-Zhong Wang, Yang Liu, Jin-Long Wang, Le Lu, Ya-Fei Zhang, Hong-Wei Lu, Yi-Ming Li, Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, Shaanxi Province, China.
Simultaneous revascularization in liver transplantation may reduce ischemic-type biliary lesions and intensive care unit (ICU) stays. This meta-analysis compared simultaneous versus sequential revascularization techniques, finding benefits for the simultaneous approach.
Area of Science:
- Hepatology
- Transplantation Surgery
- Medical Statistics
Background:
- Liver transplantation is a complex procedure with potential complications.
- Revascularization strategies, simultaneous versus sequential, may impact patient outcomes.
- Ischemic-type biliary lesions are a significant concern after liver transplantation.
Purpose of the Study:
- To conduct a meta-analysis investigating the relationship between revascularization methods and outcomes in liver transplantation.
- To compare simultaneous revascularization with sequential revascularization in liver transplant recipients.
Main Methods:
- A comprehensive literature search was performed using MeSH and keywords.
- Study quality was assessed using Jadad Score and Newcastle-Ottawa Scale.
- Heterogeneity, publication bias, and risk of bias were rigorously evaluated.
Main Results:
- Six studies with 467 patients were included in the meta-analysis.
- Simultaneous revascularization significantly reduced ischemic-type biliary lesions (OR = 4.97) and ICU days (MD = 2.00).
- While warm ischemia time was longer, other outcomes showed no significant differences between groups.
Conclusions:
- Simultaneous revascularization in liver transplantation appears to decrease the incidence of ischemic-type biliary lesions.
- This approach may also lead to a shorter length of stay in the intensive care unit (ICU).
